Information from Douglas Knueven, DVM and Vetri-Science® Laboratories
Glucosamine and chondroitin are components of healthy joints. They help the joint cartilage maintain its 65% to 80% water content. This gives the joint its shock absorbing quality like a wet sponge. Joint cartilage lacking these substances becomes like a dry sponge and develops arthritis.
Throughout an animal’s life, there are two competing processes going on in joint cartilage. On the one hand, there are cells that continuously break down joint tissue. At the same time, there are cells that rebuild the tissue. This is how the body refurbishes itself. If the raw ingredients for rebuilding, such as glucosamine and chondroitin, are lacking, then the rebuilding process cannot keep up with the destructive process and the joint degenerates.
Glucosamine and chondroitin support joint health and they not only aid with arthritis, studies show they help prevent arthritis from developing in the first place. That’s why all pets can benefit from these nutrients — especially performance dogs whose joints take a lot of wear and tear. Recent studies have also shown that many older cats also suffer in silence from arthritis.
By the way, non-steroidal anti-inflammatory drugs decrease inflammation and pain but also inhibit the cartilage reconstruction process and thereby worsen the condition they are used to treat.
What is Glycomega Brand Perna Canaliculus?
Perna canaliculus/Green Lipped Mussel from New Zealand is produced under strict government regulated standards to ensure quality and purity. The GlycOmega™ used in the Glyco-Flex® products is from an exclusive source available only to Vetri-Science. Perna canaliculus is an edible species of shellfish from New Zealand that can be freeze dried into a concentrated power. It is rich in amino acids, polypeptides, chelated minerals, fatty acids, glycosaminoglycans, vitamins, and the nucleic acids RNA and DNA. GlycOmega™ Perna contains all major classes of glycosaminoglycans (GAG’s) including chondroitin -4 and -6 sulfates that occur in connective tissue such as joint cartilage, tendons, ligaments, and synovial fluid. GAG’s are broken down and may not be replaced effectively due to age or metabolic status. As dogs and cats age, there may be an insufficient production of GAG’s and proteoglycans, which can result in joint stress, thinning of the synovial fluid, and accelerated breakdown of connective tissue. Perna naturally contains long chain unsaturated fatty acids, glycoprotein’s, GAG’s, protein complexes, and polysaccharides, which are important in maintaining healthy connective tissues.
What Role Do Amino Acids Play?
Essential and non-essential amino acids support the growth and development of all body tissues. Branched-chain amino acids provide energy directly to muscle tissue.
What Are Chelated Minerals And Why Are They Important?
It is a mineral that is attached to a protein molecule and thereby helps the body absorb the mineral effectively. Minerals like manganese and calcium are important to bone and joint health.
What is Glucosamine?
Glucosamine is an amino sugar produced in the body that provides a key building block for the synthesis of GAG’s and proteoglycans. Glucosamine is found in the tissues of tendons, ligaments, cartilage, synovial fluid, skin, heart valves and the eye.
Glucosamine has been shown to stimulate GAG synthesis in the cartilage matrix and synovial fluid. The body uses glucosamine to produce the GAG’s, which then give shape, elasticity, and rigidity to the aforementioned connective tissues as well as intervertebral discs, the interstitium and mucous membranes. A high level of GAG’s enables the joints to hold more water thereby increasing flexibility, cushioning ability, and resiliency. Glucosamine makes up fifty percent of hyaluronic acid; the principal GAG found in synovial fluid.
What are GAG’s and why are they important?
GAG’s are the principle components of cartilage and synovial fluid found in the joint. They have been referred to as the “glue of life” as they help hold together connective tissues like collagen, tendons, and ligaments. They are essential for maintaining the shock absorbency of joints.
What Is Methylsulfonylmethane?
MSM is a source of organic sulfur and is an essential mineral found in various compounds and structures in the body such as collagen, hormones, and immunoglobulins.
Sulfur as part of MSM helps the body to maintain good cell membrane flexibility and permeability, which allows for the exchange of nutrients into and toxins out of the cell. It is also involved in the formation of collagen. MSM provides organic sulfur for amino acids used to create new cells. The concentration of organic sulfur in the body can be reduced through the normal aging process and stress.
What Is Dimethylglyine?
DMG is a versatile health building factors that can help animals maintain a strong immune system. It is a natural amino acid found in the body. DMG supplies methyl groups for modification, building and detoxifying many constituents in the body and acts as an antioxidant.
What Is Manganese?
It is an essential mineral that supports many enzyme-controlled reactions. It is required for the enzyme glycosyltranferase, which is essential for the formation of collagen, GAG’s, and proteoglycans, which are all components of articular cartilage. A lack of manganese can lead to insufficient production of GAG’s in the joints.
What Role Do Antioxidants Play?
They are substances that block or inhibit destructive oxidation reactions and free radicals that cause inflammatory responses.
What Is Vitamin C?
Calcium ascorbate is the mineral calcium combined with ascorbic acid. This combination is well absorbed from the digestive tract. Calcium ascorbate has been found to be very beneficial in connective tissue health. As a mineral, calcium is vital for the formation of strong bones. It is also needed to reduce muscle cramping and for muscular growth and contraction.
Directions for Use:
|Initial: (4-6 Weeks) |
Up to 30 lbs: ½ tablet daily
31-60 lbs: 1 tablet daily
61-100 lbs: 2 tablets daily
101 lbs and over: 2 ½ tablets daily
|Maintenance: (After initial period) |
Up to 30 lbs: ½ tablet daily every other day
31-60 lbs: 1/2 tablet daily
61-100 lbs: 1 tablet daily
101 lbs and over: 1 ½ tablets daily
If giving more than 1 tablet, divide between AM and PM